Whole-flock, metaphylactic tilmicosin failed to eliminate contagious ovine digital dermatitis and footrot in sheep: a cluster randomised trial

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Whole-flock, metaphylactic tilmicosin failed to eliminate contagious ovine digital dermatitis and footrot in sheep: a cluster randomised trial

The aim of this study was to evaluate the clinical success of whole-flock systemic tilmicosin and enhanced biosecurity in eliminating active contagious ovine digital dermatitis (CODD) from sheep flocks. Thirty flocks in the UK were randomly allocated to receive either treatment as usual (as per the farmer's normal routine) or whole-flock treatment with tilmicosin, together with isolation and ex...

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Identification of spirochetes associated with contagious ovine digital dermatitis.

Spirochetes of the genus Treponema were cultured from 7 of 10 cases of digital dermatitis in sheep. Two cultures comprised Treponema phagedenis-like and Treponema medium/Treponema vincentii-like spirochetes, respectively, while the remaining cultures comprised mixed populations of Treponema medium/Treponema vincentii-like, Treponema phagedenis-like, and Treponema denticola/Treponema putidum-lik...

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Comparison of tilmicosin and lincomycin/spectinomycin combination for treatment of footrot in merino sheep

This study was conducted on a commercial New Zealand sheep farm in order to compare the cure rates of merino sheep infected with footrot. Infected sheep were treated with either lincomycin/spectinomycin combination (Linco-Spectin soluble powder, Pfizer Animal Health) or tilmicosin (Micotil 300 Injection, ELANCO) antibiotics. A flock of 3000 mixed age merino ewes had their feet inspected by the ...

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In vitro susceptibility of contagious ovine digital dermatitis associated Treponema spp. isolates to antimicrobial agents in the UK

BACKGROUND Contagious ovine digital dermatitis (CODD) is an important cause of infectious lameness in sheep in the UK and Ireland and has a severe impact on the welfare of affected individuals. The three treponemal phylogroups Treponema medium/Treponema vincentii-like, Treponema phagedenis-like and Treponema pedis spirochaetes have been associated with clinical CODD lesions and are considered t...

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Differential expression of Toll-like receptors and inflammatory cytokines in ovine interdigital dermatitis and footrot

Footrot is a common inflammatory bacterial disease affecting the health and welfare of sheep worldwide. The pathogenesis of footrot is complex and multifactorial. The primary causal pathogen is the anaerobic bacterium Dichelobacter nodosus, with Fusobacterium necrophorum also shown to play a key role in disease. Since immune-mediated pathology is implicated, the aim of this research was to inve...

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ژورنال

عنوان ژورنال: Veterinary Record

سال: 2016

ISSN: 0042-4900

DOI: 10.1136/vr.103625